Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways

T cell exhaustion plays critical roles in tumor immune evasion. Novel strategies to suppress immune evasion are in urgent need. We aimed to identify potential compounds to target T cell exhaustion and increase response to immune checkpoint inhibitors (ICIs). Differentially expressed genes (DEGs) wer...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Xiang, Zhen, Zhou, Zhijun, Song, Shuzheng, Li, Jun, Ji, Jun, Yan, Ranlin, Wang, Jiexuan, Cai, Wei, Hu, Wenjun, Zang, Lu, Zhu, Zhenggang, Zhang, Zhen, Li, Min, Yu, Yingyan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235907/
https://ncbi.nlm.nih.gov/pubmed/34175886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01897-0
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