Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α

Mitotane is the cornerstone of medical treatment of adrenocortical carcinoma. Estrogenic-like side effects frequently occur in patients, and previous studies explored the chemical nature of the interaction between estrogen receptor-α (ER-α) and toxic compounds, including the DDD derivatives. We used...

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Veröffentlicht in:Biomedicines
Hauptverfasser: Rossini, Elisa, Giacopuzzi, Edoardo, Gangemi, Fabrizio, Tamburello, Mariangela, Cosentini, Deborah, Abate, Andrea, Laganà, Marta, Berruti, Alfredo, Grisanti, Salvatore, Sigala, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235434/
https://ncbi.nlm.nih.gov/pubmed/34208714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9060681
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