A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies

Huntington's disease (HD) is a fatal autosomal‐dominant neurodegenerative disease caused by a trinucleotide CAG repeat expansion of the huntingtin gene (HTT) that affects 1 in every 10 000 individuals in the United States. Our lab developed a novel immune deficient HD mouse strain, the YACNSG,...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Transl Med
Autori principali: Dahlenburg, Heather, Cameron, David, Yang, Sheng, Bachman, Angelica, Pollock, Kari, Cary, Whitney, Pham, Missy, Hendrix, Kyle, White, Jeannine, Nelson, Haley, Deng, Peter, Anderson, Joseph S., Fink, Kyle, Nolta, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2021
Soggetti:
Enabling Technologies for Cell‐based Clinical Translation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235129/
https://ncbi.nlm.nih.gov/pubmed/33710799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.20-0431
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