Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the anti-infl...

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Pubblicato in:Pharmaceuticals (Basel)
Autori principali: Huang, Chi-Han, Wang, Shu-Chi, Chen, I-Chen, Chen, Yi-Ting, Liu, Po-Len, Fang, Shih-Hua, Huang, Shu-Pin, Yeh, Hsin-Chih, Liu, Ching-Chih, Lee, Po-Yen, Lin, Tzu-Chieh, Cheng, Wei-Chung, Su, Chia-Cheng, Wu, Hsin-En, Chen, Yuan-Ru, Li, Chia-Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8234963/
https://ncbi.nlm.nih.gov/pubmed/34207356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060588
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