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SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO mutants were embryonic lethal while SOS2-KO mice were viable led to initially...
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| 發表在: | Int J Mol Sci |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8234257/ https://ncbi.nlm.nih.gov/pubmed/34205562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126613 |
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