MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target

Pathogenic mitochondrial NADH dehydrogenase (ND) gene mutations enhance the invasion and metastasis of various cancer cells, and they are associated with metastasis in human non-small cell lung cancer (NSCLC). Moreover, monocarboxylate transporter 4 (MCT4) is overexpressed in solid cancers and plays...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Takenaga, Keizo, Koshikawa, Nobuko, Akimoto, Miho, Tatsumi, Yasutoshi, Lin, Jason, Itami, Makiko, Nagase, Hiroki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233425/
https://ncbi.nlm.nih.gov/pubmed/34172808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92772-1
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