A gain-of-function NLRP3 3′-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression

Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis. In this study, we evaluated the genetic association of NLRP3 polymor...

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Pubblicato in:Sci Rep
Autori principali: Lu, Furong, Chen, Hongpeng, Hong, Yuan, Lin, Yao, Liu, Lizhen, Wei, Ning, Wu, Qinyan, Liao, Shuanglin, Yang, Shuai, He, Junbing, Shao, Yiming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233413/
https://ncbi.nlm.nih.gov/pubmed/34172780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92547-8
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