Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

Mammalian hibernators endure severe and prolonged hypothermia that is lethal to non-hibernators, including humans and mice. The mechanisms responsible for the cold resistance remain poorly understood. Here, we found that hepatocytes from a mammalian hibernator, the Syrian hamster, exhibited remarkab...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Anegawa, Daisuke, Sugiura, Yuki, Matsuoka, Yuta, Sone, Masamitsu, Shichiri, Mototada, Otsuka, Reo, Ishida, Noriko, Yamada, Ken-ichi, Suematsu, Makoto, Miura, Masayuki, Yamaguchi, Yoshifumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233303/
https://ncbi.nlm.nih.gov/pubmed/34172811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02297-6
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