Molecular dynamics, quantum mechanics and docking studies of some Keap1 inhibitors – An insight into the atomistic mechanisms of their antioxidant potential

Inhibitors of Keap1 would disrupt the covalent interaction between Keap1 and Nrf2 to unleash Nrf2 transcriptional machinery that orchestrates its cellular antioxidant, cytoprotective and detoxification processes thereby, protecting the cells against oxidative stress mediated diseases. In this in sil...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Heliyon
Main Authors: Adelusi, Temitope Isaac, Abdul-Hammed, Misbaudeen, Idris, Mukhtar Oluwaseun, Oyedele, Qudus Kehinde, Adedotun, Ibrahim Olaide
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233138/
https://ncbi.nlm.nih.gov/pubmed/34195424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2021.e07317
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