Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations

PURPOSE: Fibroblast growth factor receptor (FGFR) 2 alterations, present in 5%-15% of intrahepatic cholangiocarcinomas (IHC), are targets of FGFR-directed therapies. Acquired resistance is common among patients who respond. Biopsies at the time of acquired resistance to targeted agents may not alway...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Varghese, Anna M., Patel, Juber, Janjigian, Yelena Y., Meng, Fanli, Selcuklu, S. Duygu, Iyer, Gopakumar, Houck-Loomis, Brian, Harding, James J., O’Reilly, Eileen M., Abou-Alfa, Ghassan K., Lowery, Maeve A., Berger, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2021
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232836/
https://ncbi.nlm.nih.gov/pubmed/34250419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00178
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