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The Role of Non-Enzymatic Degradation of Meropenem—Insights from the Bottle to the Body

Several studies have addressed the poor stability of meropenem in aqueous solutions, though not considering the main degradation product, the open-ring metabolite (ORM) form. In the present work, we elucidate the metabolic fate of meropenem and ORM from continuous infusion to the human bloodstream....

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Bibliografische gegevens
Gepubliceerd in:Antibiotics (Basel)
Hoofdauteurs: Liebchen, Uwe, Rakete, Sophie, Vogeser, Michael, Arend, Florian M., Kinast, Christina, Scharf, Christina, Zoller, Michael, Schönermarck, Ulf, Paal, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231794/
https://ncbi.nlm.nih.gov/pubmed/34198482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics10060715
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