Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen–Lysine System: Discovery of a New Ketoprofen–l-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties

Ketoprofen–l-lysine salt (KLS) is a widely used nonsteroidal anti-inflammatory drug. Here, we studied deeply the solid-state characteristics of KLS to possibly identify new polymorphic drugs. Conducting a polymorph screening study and combining conventional techniques with solid-state nuclear magnet...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Aramini, Andrea, Bianchini, Gianluca, Lillini, Samuele, Bordignon, Simone, Tomassetti, Mara, Novelli, Rubina, Mattioli, Simone, Lvova, Larisa, Paolesse, Roberto, Chierotti, Michele Remo, Allegretti, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230491/
https://ncbi.nlm.nih.gov/pubmed/34200917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060555
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