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THAP9 Transposase Cleaves DNA via Conserved Acidic Residues in an RNaseH-Like Domain

The catalytic domain of most ‘cut and paste’ DNA transposases have the canonical RNase-H fold, which is also shared by other polynucleotidyl transferases such as the retroviral integrases and the RAG1 subunit of V(D)J recombinase. The RNase-H fold is a mixture of beta sheets and alpha helices with t...

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Publicat a:Cells
Autors principals: Sharma, Vasudha, Thakore, Prachi, Majumdar, Sharmistha
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230255/
https://ncbi.nlm.nih.gov/pubmed/34072453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061351
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