β-Thujaplicin Enhances TRAIL-Induced Apoptosis via the Dual Effects of XIAP Inhibition and Degradation in NCI-H460 Human Lung Cancer Cells

Background: β-thujaplicin, a natural tropolone derivative, has anticancer effects on various cancer cells via apoptosis. However, the apoptosis regulatory proteins involved in this process have yet to be revealed. Methods: Trypan blue staining, a WST-8 assay, and a caspase-3/7 activity assay were us...

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Publicado en:Medicines (Basel)
Autores principales: Seno, Saki, Kimura, Minori, Yashiro, Yuki, Kimura, Ryutaro, Adachi, Kanae, Terabayashi, Aoi, Takahashi, Mio, Oyama, Takahiro, Abe, Hideaki, Abe, Takehiko, Tanuma, Sei-ichi, Takasawa, Ryoko
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229775/
https://ncbi.nlm.nih.gov/pubmed/34199423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/medicines8060026
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