Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice

Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic strains against the currently licensed antiviral m...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Deinhardt-Emmer, Stefanie, Jäckel, Laura, Häring, Clio, Böttcher, Sarah, Wilden, Janine J., Glück, Brigitte, Heller, Regine, Schmidtke, Michaela, Koch, Mirijam, Löffler, Bettina, Ludwig, Stephan, Ehrhardt, Christina
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228449/
https://ncbi.nlm.nih.gov/pubmed/34072389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11060808
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