Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host

Malaria parasites require pantothenate from both human and mosquito hosts to synthesize coenzyme A (CoA). Specifically, mosquito-stage parasites cannot synthesize pantothenate de novo or take up preformed CoA from the mosquito host, making it essential for the parasite to obtain pantothenate from mo...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Simão-Gurge, Raquel M., Thakre, Neha, Strickland, Jessica, Isoe, Jun, Delacruz, Lillian R., Torrevillas, Brandi K., Rodriguez, Anna M., Riehle, Michael A., Luckhart, Shirley
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228300/
https://ncbi.nlm.nih.gov/pubmed/34072373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11060807
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