Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD(+) levels and inducing SIRT1 activity. We show that the silencing of PARP2 causes mitochondrial fragmentation in myoblasts. We assessed multiple pathways that can lead t...

Full description

Saved in:
Bibliographic Details
Published in:Cells
Main Authors: Jankó, Laura, Kovács, Tünde, Laczik, Miklós, Sári, Zsanett, Ujlaki, Gyula, Kis, Gréta, Horváth, Ibolya, Antal, Miklós, Vígh, László, Bálint, Bálint L., Uray, Karen, Bai, Péter
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227884/
https://ncbi.nlm.nih.gov/pubmed/34199944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061387
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items