PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression. To tackle this issue, most mRNA delivery systems have used cationic components, which form electrostatically driven comple...

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Bibliografski detalji
Izdano u:Pharmaceutics
Glavni autori: Yoshinaga, Naoto, Naito, Mitsuru, Tachihara, Yoshihiro, Boonstra, Eger, Osada, Kensuke, Cabral, Horacio, Uchida, Satoshi
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227728/
https://ncbi.nlm.nih.gov/pubmed/34071840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060800
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