Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy

BACKGROUND AND PURPOSE: Paclitaxel, a widely used anti-cancer drug, is frequently associated with prolonged and severe peripheral neuropathies (PIPN), associated with neuroinflammation. Currently, PIPN effective treatments are lacking. Peroxisome Proliferator-Activated Receptor-α (PPAR-α) can modula...

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Bibliographic Details
Published in:Brain Behav Immun
Main Authors: CAILLAUD, Martial, PATEL, Nipa H., WHITE, Alyssa, WOOD, Mackinsey, Contreras, Katherine M., TOMA, Wisam, Alkhlaif, Yasmin, ROBERTS, Jane L., Tran, Tammy H., JACKSON, Asti B., POKLIS, Justin, GEWIRTZ, David A., DAMAJ, M. Imad
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226373/
https://ncbi.nlm.nih.gov/pubmed/33434562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2021.01.004
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