Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLCβ1-Ca(2+)-Mediated Endoplasmic Reticulum Stress

As reported in our previous study, cinaciguat can improve implant osseointegration in type 2 diabetes mellitus (T2DM) rats by reactivating type 2 cGMP-dependent protein kinase (PKG2), but the downstream mechanisms remain unclear. In the present study, we investigated the favorable effect of cinacigu...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Jia, Tingting, Wang, Ya-nan, Feng, Yao, Wang, Chenchen, Zhang, Dongjiao, Xu, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225424/
https://ncbi.nlm.nih.gov/pubmed/34221234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/5552530
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