A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional regulator serving major functions in PA virulence – can enhan...

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發表在:Adv Sci (Weinh)
Main Authors: Schütz, Christian, Ho, Duy‐Khiet, Hamed, Mostafa Mohamed, Abdelsamie, Ahmed Saad, Röhrig, Teresa, Herr, Christian, Kany, Andreas Martin, Rox, Katharina, Schmelz, Stefan, Siebenbürger, Lorenz, Wirth, Marius, Börger, Carsten, Yahiaoui, Samir, Bals, Robert, Scrima, Andrea, Blankenfeldt, Wulf, Horstmann, Justus Constantin, Christmann, Rebekka, Murgia, Xabier, Koch, Marcus, Berwanger, Aylin, Loretz, Brigitta, Hirsch, Anna Katharina Herta, Hartmann, Rolf Wolfgang, Lehr, Claus‐Michael, Empting, Martin
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224453/
https://ncbi.nlm.nih.gov/pubmed/34165899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202004369
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