Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency

In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancem...

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Dettagli Bibliografici
Pubblicato in:Pharmaceutics
Autori principali: Violaris, Ioannis G., Kalafatakis, Konstantinos, Zavala, Eder, Tsoulos, Ioannis G., Lampros, Theodoros, Lightman, Stafford L., Tsipouras, Markos G., Giannakeas, Nikolaos, Tzallas, Alexandros, Russell, Georgina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224376/
https://ncbi.nlm.nih.gov/pubmed/34064165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060769
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