Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN). Patients with aHUS are currently treated with eculizumab while the...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Aradottir, Sigridur Sunna, Kristoffersson, Ann-Charlotte, Roumenina, Lubka T., Bjerre, Anna, Kashioulis, Pavlos, Palsson, Runolfur, Karpman, Diana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222914/
https://ncbi.nlm.nih.gov/pubmed/34177949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.690821
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