Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Complement factor B (FB) mutant variants are associated with excessive complement activation in kidney diseases such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy and membranoproliferative glomerulonephritis (MPGN). Patients with aHUS are currently treated with eculizumab while the...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Aradottir, Sigridur Sunna, Kristoffersson, Ann-Charlotte, Roumenina, Lubka T., Bjerre, Anna, Kashioulis, Pavlos, Palsson, Runolfur, Karpman, Diana
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222914/
https://ncbi.nlm.nih.gov/pubmed/34177949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.690821
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