Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator

Muscle ankyrin repeat protein 1 (MARP1) is frequently up-regulated in stressed muscle, but its effect on skeletal muscle function is poorly understood. Here, we focused on its interaction with the titin–N2A element, found in titin’s molecular spring region. We show that MARP1 binds to F-actin, and t...

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Gepubliceerd in:J Gen Physiol
Hoofdauteurs: van der Pijl, Robbert J., van den Berg, Marloes, van de Locht, Martijn, Shen, Shengyi, Bogaards, Sylvia J.P., Conijn, Stefan, Langlais, Paul, Hooijman, Pleuni E., Labeit, Siegfried, Heunks, Leo M.A., Granzier, Henk, Ottenheijm, Coen A.C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222902/
https://ncbi.nlm.nih.gov/pubmed/34152365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202112925
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