A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation

R-loops are non-canonical, three-stranded nucleic acid structures composed of a DNA:RNA hybrid, a displaced single-stranded (ss)DNA, and a trailing ssRNA overhang. R-loops perform critical biological functions under both normal and disease conditions. To elucidate their cellular functions, we need t...

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Detalles Bibliográficos
Publicado en:Front Mol Biosci
Main Authors: Dettori, Leonardo G., Torrejon, Diego, Chakraborty, Arijita, Dutta, Arijit, Mohamed, Mohamed, Papp, Csaba, Kuznetsov, Vladimir A., Sung, Patrick, Feng, Wenyi, Bah, Alaji
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Molecular Biosciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222781/
https://ncbi.nlm.nih.gov/pubmed/34179096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.691694
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