Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ

Mutation of ciliopathy protein HYLS1 causes the perinatal lethal hydrolethalus syndrome (HLS), yet the underlying molecular etiology and pathogenesis remain elusive. Here, we reveal unexpected mechanistic insights into the role of mammalian HYLS1 in regulating primary cilia. HYLS1 is recruited to th...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Chen, Chuan, Xu, Qingwen, Zhang, Yuxia, Davies, Brian A., Huang, Yan, Katzmann, David J., Harris, Peter C., Hu, Jinghua, Ling, Kun
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221637/
https://ncbi.nlm.nih.gov/pubmed/34162535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3401
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