Rejection of benign melanocytic nevi by nevus-resident CD4(+) T cells

Melanoma and melanocytic nevi harbor shared lineage-specific antigens and oncogenic mutations. Yet, the relationship between the immune system and melanocytic nevi is unclear. Using a patient-derived xenograft (PDX) model, we found that 81.8% of the transplanted nevi underwent spontaneous regression...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Schiferle, Erik B., Cheon, Se Yun, Ham, Seokjin, Son, Heehwa G., Messerschmidt, Jonathan L., Lawrence, Donald P., Cohen, Justine V., Flaherty, Keith T., Moon, James J., Lian, Christine G., Sullivan, Ryan J., Demehri, Shadmehr
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221625/
https://ncbi.nlm.nih.gov/pubmed/34162549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4498
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