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The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

Although brain metastases are common in cancer patients, little is known about the mechanisms of cancer extravasation across the blood-brain barrier (BBB), a key step in the metastatic cascade that regulates the entry of cancer cells into the brain parenchyma. Here, we show, in a three-dimensional i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Hajal, Cynthia, Shin, Yoojin, Li, Leanne, Serrano, Jean Carlos, Jacks, Tyler, Kamm, Roger D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221620/
https://ncbi.nlm.nih.gov/pubmed/34162553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg8139
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