Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus-1 latency

MicroRNA miR-138, which is highly expressed in neurons, represses herpes simplex virus 1 (HSV-1) lytic-cycle genes by targeting viral ICP0 mRNA, thereby promoting viral latency in mice. We found that overexpressed miR-138 also represses lytic processes independently of ICP0 in murine and human neuro...

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Veröffentlicht in:Nat Microbiol
Hauptverfasser: Sun, Boqiang, Yang, Xuewei, Hou, Fujun, Yu, Xiaofeng, Wang, Qiongyan, Oh, Hyung Suk, Raja, Priya, Pesola, Jean M., Vanni, Emilia A. H., McCarron, Seamus, Morris-Love, Jenna, Ng, Alex H. M., Church, George M., Knipe, David M., Coen, Donald M., Pan, Dongli
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221016/
https://ncbi.nlm.nih.gov/pubmed/33558653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00860-1
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