SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer’s disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer’s disease, and SORL1 variants increase risk for late-onset AD. To understand the contribu...

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Publicado no:Cell Rep
Main Authors: Hung, Christy, Tuck, Eleanor, Stubbs, Victoria, van der Lee, Sven J., Aalfs, Cora, van Spaendonk, Resie, Scheltens, Philip, Hardy, John, Holstege, Henne, Livesey, Frederick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220253/
https://ncbi.nlm.nih.gov/pubmed/34133918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109259
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