Simvastatin-romidepsin combination kills bladder cancer cells synergistically

The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...

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Detaylı Bibliyografya
Yayımlandı:Transl Oncol
Asıl Yazarlar: Okubo, Kazuki, Miyai, Kosuke, Kato, Kimi, Asano, Takako, Sato, Akinori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2021
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/
https://ncbi.nlm.nih.gov/pubmed/34144348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154
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