Metformin Augments Panobinostat's Anti-Bladder Cancer Activity by Activating AMP-Activated Protein Kinase()()

Panobinostat, a histone deacetylase inhibitor, induces histone acetylation and acts against cancer but attenuates its anticancer activity by activating the mammalian target of rapamycin (mTOR) pathway. AMP-activated protein kinase (AMPK) is a cellular energy sensor that reportedly inhibits the mTOR...

Full description

Saved in:
Bibliographic Details
Published in:Transl Oncol
Main Authors: Okubo, Kazuki, Isono, Makoto, Asano, Takako, Sato, Akinori
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2019
Subjects:
Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402380/
https://ncbi.nlm.nih.gov/pubmed/30849634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.02.001
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items