Simvastatin-romidepsin combination kills bladder cancer cells synergistically

The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...

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Bibliographic Details
Published in:Transl Oncol
Main Authors: Okubo, Kazuki, Miyai, Kosuke, Kato, Kimi, Asano, Takako, Sato, Akinori
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2021
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/
https://ncbi.nlm.nih.gov/pubmed/34144348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154
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