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Simvastatin-romidepsin combination kills bladder cancer cells synergistically
The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...
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| Gepubliceerd in: | Transl Oncol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Neoplasia Press
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/ https://ncbi.nlm.nih.gov/pubmed/34144348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154 |
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