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Simvastatin-romidepsin combination kills bladder cancer cells synergistically
The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...
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| Izdano u: | Transl Oncol |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Neoplasia Press
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/ https://ncbi.nlm.nih.gov/pubmed/34144348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154 |
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