Simvastatin-romidepsin combination kills bladder cancer cells synergistically

The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Transl Oncol
Autores principales: Okubo, Kazuki, Miyai, Kosuke, Kato, Kimi, Asano, Takako, Sato, Akinori
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/
https://ncbi.nlm.nih.gov/pubmed/34144348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares