Simvastatin-romidepsin combination kills bladder cancer cells synergistically

The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining simvastatin with the histone deacetylase (HDAC) inhibitor romidepsin would kill bladder cancer cells by inducing histone acetylation coopera...

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Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Okubo, Kazuki, Miyai, Kosuke, Kato, Kimi, Asano, Takako, Sato, Akinori
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220249/
https://ncbi.nlm.nih.gov/pubmed/34144348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101154
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