PD-L1 upregulation is associated with activation of the DNA double-strand break repair pathway in patients with colitic cancer

Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the DNA double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) pathway can induce PD-L1 expression transcriptionall...

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izdano v:Sci Rep
Main Authors: Ozawa, Naoya, Yokobori, Takehiko, Osone, Katsuya, Katayama, Chika, Suga, Kunihiko, Komine, Chika, Shibasaki, Yuta, Shiraishi, Takuya, Okada, Takuhisa, Kato, Ryuji, Ogawa, Hiroomi, Sano, Akihiko, Sakai, Makoto, Sohda, Makoto, Ojima, Hitoshi, Miyazaki, Tatsuya, Motegi, Yoko, Ide, Munenori, Yao, Takashi, Kuwano, Hiroyuki, Shirabe, Ken, Saeki, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219733/
https://ncbi.nlm.nih.gov/pubmed/34158547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92530-3
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