KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Klotho-VS heterozygosity (KL-VS(het)) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VS(het) is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Neitzel, Julia, Franzmeier, Nicolai, Rubinski, Anna, Dichgans, Martin, Brendel, Matthias, Malik, Rainer, Ewers, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219708/
https://ncbi.nlm.nih.gov/pubmed/34158479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23755-z
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