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Stepwise evolution and exceptional conservation of ORF1a/b overlap in coronaviruses
The programmed frameshift element (PFE) rerouting translation from ORF1a to ORF1b is essential for propagation of coronaviruses. A combination of genomic features that make up PFE—the overlap between the two reading frames, a slippery sequence, as well as an ensemble of complex secondary structure e...
Guardat en:
| Publicat a: | bioRxiv |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219097/ https://ncbi.nlm.nih.gov/pubmed/34159333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.06.14.448413 |
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