Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii

Carbon catabolite repression (CCR) limits microbial utilization of lignocellulose-derived pentoses. To relieve CCR in Clostridium beijerinckii NCIMB 8052, we sought to downregulate catabolite control protein A (CcpA) using the M1GS ribozyme technology. A CcpA-specific ribozyme was constructed by tet...

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Библиографические подробности
Опубликовано в: :Front Bioeng Biotechnol
Главные авторы: Ujor, Victor Chinomso, Lai, Lien B., Okonkwo, Christopher Chukwudi, Gopalan, Venkat, Ezeji, Thaddeus Chukwuemeka
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Bioengineering and Biotechnology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217750/
https://ncbi.nlm.nih.gov/pubmed/34169065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2021.669462
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