An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency

Dengue virus (DENV), from the genus flavivirus of the family flaviviridae, causes serious health problems globally. Human monoclonal antibodies (HuMAb) can be used to elucidate the mechanisms of neutralization and antibody-dependent enhancement (ADE) of DENV infections, leading to the development of...

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Publicado no:Sci Rep
Main Authors: Kotaki, Tomohiro, Kurosu, Takeshi, Grinyo-Escuer, Ariadna, Davidson, Edgar, Churrotin, Siti, Okabayashi, Tamaki, Puiprom, Orapim, Mulyatno, Kris Cahyo, Sucipto, Teguh Hari, Doranz, Benjamin J., Ono, Ken-ichiro, Soegijanto, Soegeng, Kameoka, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217507/
https://ncbi.nlm.nih.gov/pubmed/34155267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92403-9
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