Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4(+) T Cells in Type 1 Diabetes

In Type 1 Diabetes (T1D), CD4(+) T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activation, CD4(+) T cells undergo metabolic reprogramming...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Martins, Christina P., New, Lee A., O’Connor, Erin C., Previte, Dana M., Cargill, Kasey R., Tse, Isabelle L., Sims- Lucas, Sunder, Piganelli, Jon D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216385/
https://ncbi.nlm.nih.gov/pubmed/34163475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.669456
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