Haptoglobin therapy has differential effects depending on severity of canine septic shock and cell-free hemoglobin level

BACKGROUND: During sepsis, higher plasma cell-free hemoglobin (CFH) levels portend worse outcomes. In sepsis models, plasma proteins that bind CFH improve survival. In our canine antibiotic-treated Staphylococcus aureus pneumonia model, with and without red blood cell (RBC) exchange transfusion, com...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Remy, Kenneth E., Cortés-Puch, Irene, Sun, Junfeng, Feng, Jing, Lertora, Juan J., Risoleo, Thomas, Katz, Julia, Basu, Swati, Liu, Xiaohua, Perlegas, Andreas, Kim-Shapiro, Daniel B., Klein, Harvey G., Natanson, Charles, Solomon, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216248/
https://ncbi.nlm.nih.gov/pubmed/31639229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.15567
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