Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

BACKGROUND: Genetically engineered chimeric antigen receptor (CAR) T lymphocytes are promising therapeutic tools for cancer. Four CAR T cell drugs, including tisagenlecleucel (tisa-cel) and axicabtagene-ciloleucel (axi-cel), all targeting CD19, are currently approved for treating B cell malignancies...

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Publicat a:J Transl Med
Autors principals: Haderbache, Rafik, Warda, Walid, Hervouet, Eric, da Rocha, Mathieu Neto, Trad, Rim, Allain, Vincent, Nicod, Clementine, Thieblemeont, Catherine, Boissel, Nicolas, Varlet, Pauline, Agha, Ibrahim Yakoub, Bouquet, Lucie, Guiot, Melanie, Venet, Fabienne, Sujobert, Pierre, Roussel, Xavier, Rouzaire, Paul-Oliver, Caillot, Denis, Casasnovas, Olivier, Bories, Jean Christophe, Bachy, Emmanuel, Caillat-Zucman, Sophie, Deschamps, Marina, Ferrand, Christophe
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Methodology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215786/
https://ncbi.nlm.nih.gov/pubmed/34154602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02925-z
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