Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments

BACKGROUND -: Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly. METHODS -: Our study included three fam...

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Detalhes bibliográficos
Publicado no:Circ Genom Precis Med
Main Authors: Feitosa, Mary F., Kuipers, Allison L., Wojczynski, Mary K., Wang, Lihua, Barinas-Mitchell, Emma, Kulminski, Alexander M., Thyagarajan, Bharat, Lee, Joseph H., Perls, Thomas, Christensen, Kaare, Newman, Anne B., Zmuda, Joseph M., Province, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214825/
https://ncbi.nlm.nih.gov/pubmed/33844929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.120.003201
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