Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients

BACKGROUND: The aim of this study was to identify sources of variability including patient gender and body surface area (BSA) in pharmacokinetic (PK) exposure for high-dose methotrexate (MTX) continuous infusion in a large cohort of patients with hematological and solid malignancies. METHODS: We con...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Arshad, Usman, Taubert, Max, Seeger-Nukpezah, Tamina, Ullah, Sami, Spindeldreier, Kirsten C., Jaehde, Ulrich, Hallek, Michael, Fuhr, Uwe, Vehreschild, Jörg Janne, Jakob, Carolin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214796/
https://ncbi.nlm.nih.gov/pubmed/34147089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08443-x
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