Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors

Cathelicidins such as the human 37-amino acid peptide (LL-37) are peptides that not only potently kill microbes but also trigger inflammation by enabling immune recognition of endogenous nucleic acids. Here, a detailed structure–function analysis of LL-37 was performed to understand the details of t...

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Vydáno v:J Biol Chem
Hlavní autoři: Kulkarni, Nikhil N., O’Neill, Alan M., Dokoshi, Tatsuya, Luo, Elizabeth W.C., Wong, Gerard C.L., Gallo, Richard L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214221/
https://ncbi.nlm.nih.gov/pubmed/34048712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100828
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