Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non‐medullary thyroid cancer

PURPOSE: Non-medullary thyroid cancer (NMTC) treatment is based on the ability of thyroid follicular cells to accumulate radioactive iodide (RAI). However, in a subset of NMTC patients tumor dedifferentiation occurs, leading to RAI resistance. Digoxin has been demonstrated to restore iodide uptake c...

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Vydáno v:Cell Oncol (Dordr)
Hlavní autoři: Crezee, Thomas, Tesselaar, Marika H., Nagarajah, James, Corver, Willem E., Morreau, Johannes, Pritchard, Catrin, Kimura, Shioko, Kuiper, Josephina G., van Engen-van Grunsven, Ilse, Smit, Jan W. A., Netea-Maier, Romana T., Plantinga, Theo S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8213564/
https://ncbi.nlm.nih.gov/pubmed/33534128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13402-021-00588-y
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