Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation

ABSTRACT: Liver microphysiological systems (MPSs) are promising models for predicting hepatic drug effects. Yet, after a decade since their introduction, MPSs are not routinely used in drug development due to lack of criteria for ensuring reproducibility of results. We characterized the feasibility...

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Veröffentlicht in:Clin Transl Sci
Hauptverfasser: Rubiano, Andrés, Indapurkar, Amruta, Yokosawa, Ryosuke, Miedzik, Alina, Rosenzweig, Barry, Arefin, Ayesha, Moulin, Chloe M., Dame, Keri, Hartman, Neil, Volpe, Donna A., Matta, Murali K., Hughes, David J., Strauss, David G., Kostrzewski, Tomasz, Ribeiro, Alexandre J. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212739/
https://ncbi.nlm.nih.gov/pubmed/33382907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12969
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